丝裂原激活的蛋白激酶（ＭＡＰＫ）是许多胞外促细胞增殖信号转导通路的核心环节。ＭＡＰＫ磷酸化激活多种转录因子，影响基因表达，调节细胞增殖。生长因子及一些血管活性多肽等激活血管平滑肌细胞（ＶＳＭＣ）内ＭＡＰＫ，促进ＶＳＭＣ增殖，对动脉粥样硬化、高血压病、冠脉成形术后再狭窄的发生有极重要的意义 Mitogen-activated protein kinase (MAPK) is the core of many extracellular signal transduction pathways of cell proliferation. MAPK phosphorylation activates a variety of transcription factors that affect gene expression and regulate cell proliferation. Growth factors and some vasoactive peptides activate MAPK in vascular smooth muscle cells (VSMCs) and promote the proliferation of VSMC, which is of great significance for the occurrence of atherosclerosis, hypertension and restenosis after coronary angioplasty