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目的对高危孕妇行羊水细胞染色体分析,探讨产前诊断和遗传咨询中的问题。方法分析常德市产前诊断中心1122例羊水产前诊断的结果,总结染色体异常与产前诊断指征的联系。结果成功培养1122例孕妇羊水细胞染色体,发现异常核型36例,占所有标本数3.20%,多态核型49例,占所有标本数4.36%。结论对高危指征孕妇行羊水产前诊断是一项很有必要的工作。
Objective To analyze the chromosome of amniotic fluid cells in high-risk pregnant women and discuss the problems in prenatal diagnosis and genetic counseling. Methods The results of 1122 prenatal diagnosis of prenatal amniotic fluid in Changde prenatal diagnosis center were analyzed, and the relationship between chromosomal abnormalities and prenatal diagnosis indications was summarized. Results The chromosome of amniotic fluid cells were successfully cultured in 1122 pregnant women. The abnormal karyotypes were found in 36 cases, accounting for 3.20% of all specimens and 49 polymorphic karyotypes accounting for 4.36% of all specimens. Conclusions The diagnosis of prenatal amniotic fluid in pregnant women with high risk indications is a very necessary work.