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目的:观察采用更昔洛韦联合皮质类固醇治疗角膜内皮炎疗效。方法:将30例角膜内皮炎患者随机分成两组,对照组15例(15眼):局部给予阿昔洛韦眼药水眼膏点眼。治疗组15例(15眼):局部给予典必殊、更昔洛韦等眼药水眼膏点眼全身给皮质类固醇治疗观察疗效并进行随访,进行比较。结果:对照组治愈4眼,好转7眼,无效3眼,复发率为33.3%。治疗组治愈10眼,好转4眼,复发率为6.67%。治疗组疗效和复发率均优于对照组(P<0.05)。结论:临床应用更昔洛韦联合皮质类固醇治疗角膜内皮炎能提高疗效,缩短病程,降低复发率,具有较好的治疗和抗复发效果,临床效果良好。
Objective: To observe the effect of combined use of ganciclovir and corticosteroids in the treatment of corneal endothelitis. Methods: Thirty patients with corneal endothelitis were randomly divided into two groups, 15 cases (15 eyes) in the control group: topical acyclovir eye drops ointment. In the treatment group, 15 cases (15 eyes) were treated with topical ophthalmic orally given ganciclovir and topical ophthalmic ganciclovir for corticosteroid treatment and were followed up for comparison. Results: In the control group, 4 eyes were cured, 7 eyes improved, 3 eyes were ineffective, and the recurrence rate was 33.3%. The treatment group cured 10 eyes, improved 4 eyes, the recurrence rate was 6.67%. The curative effect and recurrence rate in the treatment group were better than those in the control group (P <0.05). Conclusion: The clinical application of ganciclovir combined with corticosteroids in the treatment of corneal endothelitis can improve the curative effect, shorten the course of disease and reduce the recurrence rate. It has good therapeutic effect and anti-relapse effect, and has good clinical effect.