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目的:了解我院药品不良反应(ADR)发生的特点。方法:对我院2006年1月至2009年8月收集到的67例ADR报告进行回顾性统计分析。结果:我院报告ADR例数最多的部门为新生儿,有51例(76.12%);0～28 d年龄段患儿ADR发生率较高(52.23%),且男性高于女性;静脉给药方式是导致ADR的主要因素(97.01%);ADR发生率最高的为抗感染药(80.56%),其中绝大多数是由头孢菌素类和青霉素类引发;临床表现以皮肤及其附件损害最为常见(88.41%)。结论:儿童用药更应该加强ADR的监测,提高ADR报告的质量,合理、规范使用药物,尤其是抗菌药物,以减少或避免ADR的发生。
Objective: To understand the characteristics of drug adverse reactions (ADR) in our hospital. Methods: A retrospective statistical analysis of 67 ADR cases collected in our hospital from January 2006 to August 2009 was conducted. Results: In our department, 51 cases (76.12%) had the highest number of ADRs. The incidence of ADR was higher in children aged 0-28 years (52.23%) than in women The main cause of ADR was 97.01%. The highest incidence of ADR was anti-infective (80.56%), the majority of which were caused by cephalosporins and penicillins. The most common cause of ADR was skin and its accessories Common (88.41%). Conclusion: Children’s medication should strengthen the monitoring of ADR, improve the quality of ADR report, reasonably and regulate the use of drugs, especially antibiotics to reduce or avoid the occurrence of ADR.