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目的:探讨E-和P-选择素与脑梗死的关系。方法应用ELISA方法测定30例脑梗死患者,25例脑出血患者及28例正常人的sE-和sP-选择素血清水平。结果 急性期脑便死患者sE-和sP-选择素血清水平明显高于脑出血患者及正常人。急性期脑梗死患者sE-和sP-选择素水平分别与WBC、N％、IL-6水平呈正相关关系,sP-选择素水平还与TNF水平呈正相关关系。结论sE-和sP-选择素血清水平增高反映脑便死急性期E-和P-选择素可能在TNF和IL-6的刺激下,参与脑梗死损伤过程。
Objective: To investigate the relationship between E- and P-selectin and cerebral infarction. Methods Serum levels of sE- and sP-selectin in 30 patients with cerebral infarction, 25 patients with cerebral hemorrhage and 28 healthy controls were measured by ELISA. Results Serum levels of sE- and sP-selectin in patients with cerebral hemorrhage were significantly higher than those in patients with cerebral hemorrhage and normal controls. The levels of sE- and sP-selectin in patients with acute cerebral infarction were positively correlated with the levels of WBC, N% and IL-6, respectively. The levels of sP-selectin and TNF were positively correlated. Conclusions Increased serum levels of sE- and sP-selectin reflect acute brain injury. E- and P-selectin may be involved in the process of cerebral infarction injury stimulated by TNF and IL-6.