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本文对19例中药雷公藤服用者精子、精浆中乳酸脱氢酶(LDH)及同功酶C_4(LDHC_4)的活性进行了测定分析。发现服药后以单位数量精子表示的LDHC_4活性在精子、精浆中均有明显升高(双侧非参数秩和检验,分别为P<0.01和P<0.02);通过酶活性与精子计数的相关分析,显示服药后精浆LDHC_4活性(mU/ml)与精子计数的正相关性(r=0.2279)较服药前(r=0.5505)弱,可能与精液中精子以外的其他LDHC_4来源贡献增大有关,诸如生精细胞的分解增多等。本文认为服药后精子LDHC_4活性上升,精液中非成熟精子比例增高是其原因之一。
In this paper, the activities of lactate dehydrogenase (LDH) and isoenzyme C_4 (LDHC_4) in sperms and seminal plasma of 19 Chinese herbal medicine Tripterygium wilfordii were analyzed. The activity of LDHC_4 expressed in spermatozoa and seminal plasma after treatment was found to be significantly increased in both sperm and seminal plasma (bilateral non-parametric rank sum test, P<0.01 and P<0.02, respectively); correlation between enzyme activity and sperm count The analysis showed that the positive correlation (r=0.2279) of seminal plasma LDHC_4 activity (mU/ml) with sperm count was weaker than that before drug administration (r=0.5505), which may be related to the increased contribution of other LDHC_4 sources other than spermatozoa in semen. , such as the increased decomposition of spermatogenic cells. This article believes that the activity of sperm LDHC_4 increases after taking the drug, and the proportion of immature sperm in semen is one of the reasons.