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目的:评价在单次手术中行导管消融和左心耳封堵术的心房颤动（以下简称房颤）“一站式”治疗的安全性及短期随访结果。研究对象:连续纳入上海交通大学医学院附属新华医院2017年3月至2019年10月收治的461例非瓣膜性房颤患者。其中，男性254例，年龄（69.4±7.8）岁；平均CHAn 2DSn 2-VASc评分3.2±1.5，HAS-BLED评分2.2±1.1。n 干预措施:在单次手术中进行房颤消融和Watchman封堵器行左心耳封堵术的“一站式”治疗。观测指标及测量方法:评估患者的基线特征、围手术期参数及术后100 d随访资料，包括操作相关并发症（如心包填塞、封堵器栓塞、冠状动脉气栓和血管穿刺并发症）、卒中、出血、术后急性左心衰竭、心力衰竭再入院、急性冠状动脉综合征、需要再次消融的房颤或心房扑动复发和死亡。结果:461例患者均成功完成肺静脉隔离，其中233例患者附加线性消融和／或心房基质改良。Watchman左心耳封堵器植入成功461例（100%）。术后100 d共观察到严重不良事件34例（7.8%），包括心包积液8例（1.7%）、卒中5例（1.2%）、血管穿刺并发症5例（1.2%）、出血3例（0.7%）、术后急性左心衰竭／心力衰竭再住院9例（2.2%）、急性冠状动脉综合征1例（0.2%）和需要再次消融的房颤或心房扑动复发3例（0.7%），无封堵器栓塞和死亡发生。结论:对高卒中风险的非瓣膜性房颤患者，导管消融联合左心耳封堵术“一站式”治疗安全、可行，且具有良好的短期有效性。长期有效性有待进一步随访。“,”Objective:To evaluate the safety and results of 3 months follow-up in patients performing catheter ablation of atrial fibrillation (AF) and left atrial appendage closure (LAAC) in a single procedure.Subjects:Between March 2017 and October 2019, 461 [254 males (55.1%), aged (69.4±7.8) years] patients with non-valvular AF were consecutively enrolled for the combined procedure of catheter ablation and LAAC in Xinhua Hospital, Shanghai Jiao Tong University School of Medicine. The mean scores of CHAn 2DSn 2-VASc and HAS-BLED were 3.2±1.5 and 2.2±1.1, respectively.n Interventions:Catheter ablation of AF and LAAC with Watchman device were performed in a single procedure.Main Outcomes and Measurements:Serious adverse events (SAE) were measured at 100 days after the procedure, including pericardial effusion, stroke, systemic embolism, coronary air embolism, device embolism, vascular access complication, bleeding, perioperative acute heart failure or heart failure rehospitalization, acute coronary syndrome, recurrent AF or atrial flutter requiring redo ablation and death.Results:Pulmonary vein isolation was achieved in all patients and additional linear ablation was applied in 233 patients. Watchman device was successfully implanted in all patients. At 100 days follow-up, SAE occurred in 34 patients (7.8%), including 8 (1.7%) cases of pericardial effusion, 5 (1.2%) cases of stroke, 5 (1.2%) cases of vascular puncture complication, 3 (0.7%) cases of bleeding, 9 (2.2%) cases of perioperative acute heart failure or heart failure rehospitalization, 1 (0.2%) cases of acute coronary syndrome, and 3 (0.7%) cases of recurrent AF or atrial flutter requiring redo ablation. There was no device embolization or death at 100 days.Conclusion:The short-term outcomes support the feasibility and safety of the combined procedure of catheter ablation and LAAC in non-valvular AF patients with high stroke risk.