我院自1977年1月至1978年6月对反复发作长期不愈的病毒性心肌炎患者22例,应用免疫核糖核酸(下称iRNA)治疗,并观察治疗前后的免疫状态、症状、体征、心电图等改变。本组22例中男9例,女13例:年龄4～59岁。全组在急性期均经诊断为急性病毒性心肌炎,伴有病毒感染史。发病前无心脏病史。病程在一年以内者7例,一年以上者15例。在用iRNA前,曾用强的松及对伴有心律失常者用各种抗心律失常药数月至一年以上无效。其中除一例4岁儿童外,长期全休者15例,半休及轻工作者6例。治疗前结核菌素试验1:2,000阴性者16例,阳性者6例。花环试验(RFC)均低于正常(正常值50％～70％)。冶疗方法:iRNA系自正常人周围白细胞中提取,每支3毫克,每2周注射一次。应用iRNA溶剂溶解后,注 Our hospital from January 1977 to June 1978 for recurrent chronic viral myocarditis in 22 patients, the application of immune RNA (hereinafter referred to as iRNA) treatment, and observed before and after treatment of immune status, symptoms, signs, electrocardiogram Change. The group of 22 patients, 9 males and 13 females: aged 4 to 59 years. The whole group in the acute phase were diagnosed as acute viral myocarditis, with a history of viral infection. No history of heart disease before onset. Duration of less than one year in 7 cases, more than one year in 15 cases. In the use of iRNA before, had with prednisone and associated with arrhythmia with a variety of anti-arrhythmic drugs for months to more than one year is invalid. Among them, in addition to a 4-year-old child, the long-term complete remission in 15 cases, half-time and light workers in 6 cases. Before treatment, tuberculin test 1: 2,000 negative in 16 cases, positive in 6 cases. Rosette test (RFC) was lower than normal (normal 50% ~ 70%). Methods of treatment: iRNA from normal white blood cells in the extraction, each 3 mg, every 2 weeks injections. After iRNA solvent is dissolved, note