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目的:通过波谱学对盐酸坦索罗辛化学结构进行分析。方法:测定了盐酸坦索罗辛的核磁共振氢谱(1HNMR)、无畸变极化转移增强谱(DEPT)、核磁共振碳谱(13CNMR)、氢-氢相关谱(1H-1HCOSY)、碳氢相关谱(HMQC)、碳氢远程相关谱(HMBC)、质谱(MS)、红外光谱(FT-IR)和紫外光谱(UV),并进行结构分析和讨论。结果:该化合物的1HNMR和13CNMR谱的所有谱峰均得到合理的归属,其FT-IR吸收峰所对应的官能团振动形式、MS的分子主要碎片以及紫外特征吸收均能得到合理的解释。结论:上述各种图谱分析数据均能与盐酸坦索罗辛的结构式相吻合。
OBJECTIVE: To analyze the chemical structure of tamsulosin hydrochloride by spectroscopy. Methods: The 1H NMR, DEPT, 13CNMR, 1H-1HCOSY, hydrogen-hydrogen correlation spectroscopy (1H-1HCOSY) HMQC, HMBC, MS, FT-IR and UV spectroscopy, and the structural analysis and discussion were carried out. Results: All the peaks of 1HNMR and 13CNMR spectra of the compounds were assigned rationally. The vibrational modes of functional groups corresponding to the FT-IR absorption peaks, the major molecular fragments of MS and the absorption of UV were all reasonably explained. CONCLUSION: The above data of all the graphs can be consistent with the structural formula of tamsulosin hydrochloride.