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目的合成抗哮喘药盐酸川丁特罗。方法以2-三氟甲基苯胺为起始原料,经碘代、酰化、取代、Stephen还原、水解、氯代、Wittig反应、环氧化、胺化和成盐10步反应制得盐酸川丁特罗。结果与结论目标化合物的总收率为5.71%,其结构经质谱、1H-NMR谱确证。改进后的合成工艺缩短了步骤、简化了操作、降低了合成成本,适合工业化生产。
Objective To synthesize anticholinergic chondrotol hydrochloride. Methods 2-Trifluoromethylaniline was used as the starting material to prepare Hydrochloric acid by iodination, acylation, substitution, Stephen reduction, hydrolysis, chlorination, Wittig reaction, epoxidation, amination and salt formation Tricot. Results and Conclusion The total yield of the target compound was 5.71%. Its structure was confirmed by mass spectrometry and1H-NMR. The improved synthesis process shortens the process, simplifies the operation, reduces the synthesis cost and is suitable for industrialized production.