应激性溃疡(stress ulcer,SU)是颅脑损伤(traumatic brain injury,TBI)的常见并发症,极易增加患者的死亡率与致残率,并有严重的出血风险。以严重TBI等为应激源,所引发的应激性溃疡称为Cushing溃疡(Cushing’s ulcer)。对于Cushing溃疡,现有的国内研究报道较少并且临床的死亡率、致残率较高。因此文章主要对近5年内Cushing溃疡的机制以及中医病机进行了综述,并对其研究现状以及未来的发展等进行了全面的论述。 Stress ulcer (SU) is a common complication of traumatic brain injury (TBI), which easily increases the mortality and morbidity of patients and poses a serious risk of bleeding. With severe TBI as a stress source, the induced stress ulcer is called Cushing’s ulcer. For Cushing ulcer, there are few reports of existing domestic studies and clinical morbidity and mortality. Therefore, the article mainly summarizes the mechanism of Cushing ulcer and the pathogenesis of TCM in the past 5 years, and gives a comprehensive exposition of its research status and future development.