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本文应用核仁组成区蛋白（ＡｇＮｏＲｓ）计数对１４例ＲＢ进行研究，按肿瘤细胞分化程度可分为分化差和分化好的两大类型：分化差８例，其中７例侵犯视神经，发病年龄在３岁以前。分化好的６例，其中１例侵犯视神经，发病年龄在３岁以后。结果显示，ＲＢ的ＡｇＮｏＲｓ计数越低，肿瘤分化越好，发病年龄愈晚，患者预后较好，反之预后差；我们认为，ＡｇＮｏＲｓ定量计数可作为光镜下判断ＲＢ的恶性程度的重要指标。同时对临床治疗方案有一定的指导意义。
In this study, 14 cases of RB were studied by counting the number of nucleolar organizer regions (AgNoRs). According to the degree of tumor cell differentiation, they can be divided into two types: poorly differentiated and well differentiated. Among them, 8 cases were poorly differentiated, of which 7 cases invaded the optic nerve, 3 years old ago. Differentiated in 6 cases, of which 1 violation of the optic nerve, the age of onset after 3 years of age. The results showed that the lower the AgNoRs counts of RB, the better the tumor differentiation, the later the onset of disease, the better the prognosis of the patients and the worse prognosis. In our opinion, quantitative counting of AgNoRs can be used as an important index to judge the malignancy of RB under light microscope. At the same time, clinical treatment programs have some guiding significance.