论文部分内容阅读
目的：探讨丹参提取物Ｆ的胃粘膜保护作用与氧自由基的关系。方法：复制失血性休克再灌注损伤模型，３１只大鼠随机分为单纯失血组（ＨＥ，ｎ＝９），生理盐水对照组（ＮＳ，ｎ＝１０）及丹参提取物Ｆ组（ＤＳＥＦ，ｎ＝１２）；ＨＥ组大鼠在失血性休克２０ｍｉｎ后处死，ＮＳ及ＤＳＥＦ组则在休克２０ｍｉｎ后回输全部放出的血液，维持２０ｍｉｎ后处死。其中ＮＳ组静滴ＮＳ００３ｍｌ／ｍｉｎ，ＤＳＥＦ组静滴ＤＳＥＦ１ｇ／１００ｇｗｔ。结果：ＨＥ组损伤指数为０，ＤＳＥＦ组损伤指数明显低于ＮＳ组（Ｐ＜００１），ＤＳＥＦ组的丙二醛（ＭＤＡ）含量明显低于ＮＳ组（Ｐ＜００１），而超氧化物歧化酶（ＳＯＤ）活性明显高于ＮＳ组（Ｐ＜００１）。结论：ＤＳＥＦ在再灌注损伤中可减轻氧自由基对胃粘膜的损伤
Objective: To investigate the protective effect of Salvia miltiorrhiza extract on gastric mucosa and oxygen free radicals. METHODS: In hemorrhagic shock-reperfusion injury model, 31 rats were randomly divided into simple blood loss group (HE, n=9), saline control group (NS, n=10) and Danshen extract F group (DSEF, n=12); HE group rats were sacrificed 20 minutes after hemorrhagic shock, while NS and DSEF groups returned all released blood 20 minutes after shock, and were sacrificed after 20 minutes of maintenance. In the NS group, the NS0 03 ml/min, and the DSEF group, the DSEF 1g/100 gwt. Results: The injury index of the HE group was 0, the DSEF group’s injury index was significantly lower than that of the NS group (P<001), and the malondialdehyde (MDA) content of the DSEF group was significantly lower than that of the NS group (P<001). The activity of superoxide dismutase (SOD) was significantly higher than that of NS group (P<001). CONCLUSION: DSEF can reduce the damage of oxygen free radicals on gastric mucosa in reperfusion injury.