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缺血再灌注损伤在无复流病理生理中起核心作用.自噬在缺血再灌注损伤病理过程中起“双刃剑”作用.组织因子途径抑制物对组织因子介导的伴有炎症通路和凝血系统激活的无复流可能起到有效地预防及治疗作用.现就组织因子途径抑制物、心肌无复流与自噬的关系做一综述.“,”Ischemia reperfusion injury plays a central role in the pathophysiology of no-reflow phenomenon .Autophagy plays a role of a“double edged sword” in the pathological process of ischemia reperfusion injury .Tissue factor pathway inhibitor may play an effective role in preventing and treating tissue factor-induced no-reflow of inflammatory pathways and activation of the coagulation system .In this paper,the relationship between tissue factor pathway inhibitor ,myocardial no-reflow and autophagy was reviewed .