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目的:研究肝癌病人接受肝切除术后使用ω-3脂肪乳对术后恢复的影响。方法:选择接受手术治疗的肝癌病人60例,随机分为两组,术后等氮、等热量PN支持。研究组病人使用中长链脂肪乳联合ω-3脂肪乳;对照组病人单纯使用中长链脂肪乳。分别于术后第1和第5天清晨抽取静脉血,检测肝功能、凝血功能、免疫球蛋白、淋巴细胞亚群等。同时记录病人全身炎症反应综合征(SIRS)发生率、感染性并发症发生率、术后住院时间和住院费用等。结果:研究组病人术后ALT、AST、总胆红素(TBIL)、ALB、PA等恢复优于对照组;凝血酶原时间(PT)、凝血酶原时间活动度(PTa)两组无显著性差异;研究组病人IgA、IgG、IgM、CD3、CD4/CD8等优于对照组(P<0.05);两组病人感染性并发症发生率、SIRS发生率、肝功能不全发生率均无显著性差异。结论:ω-3脂肪乳有助于改善肝癌病人肝切除术后免疫功能和肝功能。
Objective: To study the effect of omega-3 fat emulsion on postoperative recovery in patients with liver cancer after hepatectomy. Methods: Sixty patients with hepatocellular carcinoma (HCC) undergoing surgical treatment were randomly divided into two groups. Nitrogen and other calorie PN support after operation. In the study group, the long-chain fat emulsion combined with omega-3 fat emulsion was used. In the control group, the long-chain fat emulsion was used only. Venous blood was drawn on the first and fifth postoperative day respectively to detect liver function, coagulation function, immunoglobulin, lymphocyte subsets and so on. Meanwhile, the incidence of systemic inflammatory response syndrome (SIRS), the incidence of infectious complications, postoperative hospital stay and hospitalization expenses were recorded. Results: The postoperative ALT, AST, total bilirubin (TBIL), ALB, PA in the study group were better than those in the control group. Prothrombin time (PT) and PTa in both groups were not significantly different (P <0.05). There was no significant difference in incidence of infectious complications, incidence of SIRS and hepatic insufficiency between the two groups in terms of IgA, IgG, IgM, CD3, CD4 / CD8, Sex differences. Conclusion: Omega-3 lipid emulsion can improve the immune function and liver function after liver resection in patients with liver cancer.