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目的查明广州市2例流脑病例的感染来源、流行特征,为流脑预防控制提供依据。方法采用流行病学调查方法进行回顾性调查,采集病例血液、脑脊液及密切接触者的咽拭子样本进行脑膜炎奈瑟菌分离鉴定,采用K-B和Etest法进行药敏试验,采用多位点序列分析方法进行菌株同源性分析。结果 2例病例分别为3、4月龄婴儿,临床分型均为暴发型流脑;病例的血液、脑脊液样本及密切接触者的咽拭子样本均培养出B群脑膜炎奈瑟菌。病例1及其外婆检出的B群脑膜炎奈瑟菌对12种抗生素的药敏结果完全一致,同源性分析结果显示同源性为100%;病例2及其爷爷检出的B群脑膜炎奈瑟菌对12种抗生素的药敏结果也完全一致,同源性分析结果显示同源性为100%。结论根据2例病例的流行病学特征、临床表现、实验室检测结果,判断该2例病例为B群脑膜炎奈瑟菌引起的暴发型流脑病例,病例间无关联,为散发疫情。
Objective To identify the source and epidemic features of 2 cases of meningoencephalitis in Guangzhou and provide the basis for prevention and control of meningitis. Methods A retrospective investigation was conducted by means of epidemiological investigation. Throat swab specimens from blood, cerebrospinal fluid (CSF) and close contact persons were collected for Neisseria meningitidis isolation and identification. KB and Etest methods were used for drug susceptibility testing. Multiple site sequences Analysis of homology analysis. Results The 2 cases were 3 and 4 months old infants, respectively. The clinical classification was fulminant meningitis. Neisseria meningitidis group B was cultured in blood and cerebrospinal fluid samples and throat swab samples from close contacts. Neisseria meningitidis group B and Neisseria meningitidis group B were completely consistent with the antibiotic susceptibility results of the 12 antibiotics. The homology analysis showed that the homology was 100%. Case 2 and his grandfather’s group B The susceptibility of Neisseria gonorrhoeae to the 12 antibiotics was also identical, and homology analysis showed that the homology was 100%. Conclusion According to the epidemiological characteristics, clinical manifestations and laboratory test results of 2 cases, the two cases were considered as outbreaks of meningitis meningitidis caused by Neisseria meningitidis. There was no association between the cases and the epidemic situation.