在Ｗｉｓｔａｒ大鼠肝左叶被膜下接种Ｗａｌｋｅｒ－２５６系肝癌组织６天后，将５－氟尿嘧啶硅橡胶囊控释植入剂（５－ＦｕＣＩ）植入肿瘤所在的肝左叶，观察其抑瘤率及带瘤大鼠生存时间，并与对照组及５－ＦｕＣＩ放置于肝右叶组相比较。结果表明：３组动物３０天生存率分别为１００％、３３．３％及５０％。实验组动物抑瘤率为９６．３％，且动物生存时间较其它两组明显延长（Ｐ＜０．０５），光镜下可见大量癌细胞坏死。 Wisk rats were inoculated with Walker-256 hepatocarcinoma under the capsule of the left liver for 6 days. 5-Fluorouracil silicone rubber capsule controlled-release implant (5-FuCI) was implanted into the left hepatic lobe of the tumor to observe the tumor inhibition rate. The survival time of the tumor-bearing rats was compared with that of the control group and 5-FuCI in the right hepatic lobe group. The results showed that the 30-day survival rates of the three groups of animals were 100%, 33.3%, and 50%, respectively. The tumor inhibition rate of the experimental group was 96.3%, and the survival time of the animals was significantly longer than that of the other two groups (P<0.05). A large number of cancer cell necrosis was observed under light microscope.