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黄连素即小檗碱,广泛存在于三颗针、十大功劳、黄柏等植物中。作者将黄柏片用冰醋酸:浓硫酸:水=1:1:100(重量比)溶液浸泡24小时,搅拌、过滤,如法再浸泡一次,过滤。合并两次滤液。碱化(加石灰乳),使其pH=8～9,过滤。滤液用盐酸酸化,再加入5～8％NaCl,得沉淀盐酸黄连素粗品。粗品用70％乙醇重结晶,得精品。作者试验认为,提取液加与不加醋酸,对黄连素产量有一定影响。加醋酸可显著提高效率。从黄柏中提取黄连素还可以用8％的石灰乳,效率没有硫酸提取法理想,但用酸法提取,由于黄柏树皮含有大量的粘液质,不易过滤。采用石灰提,可以避免此缺点。
Berberine is berberine, which is widely found in plants such as three needles, Mahonia and Phellodendron. The author immersed Huang Pei tablets in glacial acetic acid: concentrated sulfuric acid: water = 1:1:100 (by weight) solution for 24 hours, stir, filter, and soak again once, and filter. Combine the two filtrates. Alkaline (calcium milk), pH = 8-9, and filtered. The filtrate was acidified with hydrochloric acid, and then 5-8% NaCl was added to precipitate crude berberine hydrochloride. The crude product was recrystallized from 70% ethanol to obtain a fine product. The authors concluded that extracts with and without acetic acid have a certain effect on berberine production. Adding acetic acid can significantly increase efficiency. Extracting berberine from Phellodendron can also use 8% lime milk. The efficiency is not ideal for the extraction of sulphuric acid. However, with the acid extraction method, the bark of the cypress contains a lot of mucilage and is not easy to filter. With lime extraction, this disadvantage can be avoided.