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目的:观察胰岛素增敏剂治疗多囊卵巢综合征内分泌紊乱的临床疗效。方法:选取我院收治的148例多囊卵巢综合征内分泌紊乱患者作为研究对象,随机分为观察组和对照组,各74例,对照组常规应用达英-35进行治疗,观察组联合应用达英-35和二甲双胍。观察、比较两组患者的临床疗效。结果:观察组患者治疗后的黄体生成素、黄体生成素/卵泡刺激素、腰/臀比、BMI值均显著低于对照组,P<0.05;观察组治疗后的胰岛素抵抗指数平均值为3.12±1.23,对照组为5.53±1.88,组间比较,差异具有统计学意义(P<0.05)。结论:胰岛素增敏剂治疗多囊卵巢综合征内分泌紊乱,可有效提高胰岛素敏感性,减轻胰岛素抵抗,改善内分泌紊乱症状,临床疗效确切,具有重要的临床应用价值。
Objective: To observe the clinical efficacy of insulin sensitizer in the treatment of endocrine disorders of polycystic ovary syndrome. Methods: A total of 148 patients with endocrine disorders of PCOS admitted to our hospital were randomly divided into observation group (74 cases) and control group (74 cases). The control group was treated with up to -35, while the control group Ying-35 and metformin. Observed, compared the clinical efficacy of two groups of patients. Results: The levels of luteinizing hormone, luteinizing hormone / follicle stimulating hormone, waist / hip ratio and BMI in the observation group were significantly lower than those in the control group (P <0.05). The average insulin resistance index in the observation group after treatment was 3.12 ± 1.23 in the control group and 5.53 ± 1.88 in the control group. The differences between the two groups were statistically significant (P <0.05). CONCLUSION: Insulin sensitizer is an effective treatment for polycystic ovary syndrome endocrine disorders, which can effectively improve insulin sensitivity, reduce insulin resistance and improve the symptoms of endocrine disorders. The clinical efficacy is definite and has important clinical value.