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目的:分析抗菌药物的不良反应报告,探讨抗菌药物的合理使用问题;方法:从上海市药品不良反应监测中心2003年上半年收集的ADR报告中应用抗菌药物出现不良反应248例进行逐项统计整理。结果:在收集的药品不良反应报告中0-10岁小儿和60-90岁老年人居多,共123例,占50%。发现既往有药物不良反应史病人63例,占25%。药物不良反应表现大多数为变态反应共181例,占67%。在抗菌药物的给药方法上以静脉滴注为主,共199例,占80%。以及在用药后5分钟到1天内出现不良反应有135例,占54%。结论:合理安全使用抗菌素,减少和避免不良反应的发生。
OBJECTIVE: To analyze the adverse reactions of antimicrobials and explore the rational use of antimicrobials.Methods: 248 cases of adverse reactions of antimicrobials were collected from the ADR reports collected by Shanghai Center for Drug Adverse Reaction Monitoring in the first half of 2003 . Results: There were 123 cases (50%) of children aged 0-10 years old and 60-90 years old who were collected adverse drug reaction reports. Found that there are 63 patients with past history of adverse drug reactions, accounting for 25%. The majority of adverse drug reactions showed a total of 181 cases of allergic reactions, accounting for 67%. In the antimicrobial drug delivery method to intravenous infusion, a total of 199 cases, accounting for 80%. And in the medication within 5 minutes to 1 days after adverse reactions in 135 cases, accounting for 54%. Conclusion: The rational and safe use of antibiotics, reduce and avoid the occurrence of adverse reactions.