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自从1960年开始使用口服避孕药后,至今已有相当大的发展。因为口服避孕药有增加血栓形成的危险性,许多口服避孕药中已将乙炔雌二醇的剂量减少至30μg。以后在流行病学调查数据中发现心脏缺血性疾病的危险性与血脂蛋白的浓度有一定的关系,因此又把注意力集中到避孕药的孕激素中。
Since the introduction of oral contraceptive pills in 1960, considerable progress has been made so far. Because oral contraceptives increase the risk of thrombosis, many oral contraceptives have reduced the dose of ethinyl estradiol to 30 μg. Later in the epidemiological survey data found that the risk of ischemic heart disease and serum lipoprotein concentration has a certain relationship, so again to focus on the progestin in the contraceptives.