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目的探讨血清脂联素(ADP)水平变化与妊娠糖尿病(GDM)患者的相关性。方法选取我院2010年1月—2013年1月我院妇产科收治的100例GDM患者作为GDM组,另选择同期正常妊娠、OGTT血糖正常的孕妇100例作为对照组。空腹测定二组ADP,总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C),空腹血糖(FBG)、餐后血糖(PBG),空腹胰岛素(FINS)、餐后胰岛素(PINS),并计算胰岛素抵抗指数(HOMA-IR)。比较二组的各指标,并分析血清ADP与其他指标的相关性。结果二组血脂TG、TC、HDL-C及LDL-C水平比较差异无统计学意义(P>0.05)。GDM组FBG及PBG水平均高于对照组,FINS和PINS水平均高于对照组,ADP水平低于对照组,IR高于对照组,差异均有统计学意义(P<0.01或P<0.05)。GDM组ADP水平与FBG、FINS、HOMA-IR及TG呈显著负相关。结论低水平ADP不仅可以反映胰岛素抵抗状态的程度,而且反映糖代谢异常的变化趋势,可作为GDM发病和预后的重要指标。
Objective To investigate the relationship between serum adiponectin (ADP) levels and gestational diabetes mellitus (GDM). Methods 100 cases of GDM patients admitted to our hospital from January 2010 to January 2013 were selected as GDM group. Another 100 pregnant women with normal pregnancy and normal blood glucose of OGTT were selected as the control group. Fasting plasma glucose (ADP), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), postprandial blood glucose (PBG), fasting insulin (FINS), postprandial insulin (PINS), and calculated insulin resistance index (HOMA-IR). The indexes of two groups were compared and the correlation between serum ADP and other indexes was analyzed. Results There was no significant difference in TG, TC, HDL-C and LDL-C levels in the two groups (P> 0.05). The levels of FBG and PBG in GDM group were higher than those in control group, the levels of FINS and PINS were higher than those in control group, while the levels of ADP in control group and GDM group were lower than those in control group (P <0.01 or P <0.05) . ADP levels in GDM group were significantly negatively correlated with FBG, FINS, HOMA-IR and TG. Conclusion Low-level ADP can not only reflect the degree of insulin resistance, but also reflect the changing trend of abnormal glucose metabolism, which can be used as an important indicator of the incidence and prognosis of GDM.