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应用肺腺癌细胞株Ａ５４９作为靶细胞，探讨ＬＡＫ细胞与抗癌药物协同杀伤肿瘤细胞的作用。浓度为１０μｇ／ｍｌ～０．１５５μｇ／ｍｌ的丝裂霉Ｃ、阿霉素、顺铂３种抗瘤药物作用于Ａ５４９细胞２４或４小时以后，再加入ＬＡＫ细胞并用乳酸脱氢酶释放法测定细胞毒作用。结果显示，丝裂霉素不改变细细胞对ＬＡＫ细胞的敏感性、阿霉素的作用可随浓度增加使ＬＡＫ细胞对肿瘤细胞的杀伤作用增强。而顺铂则在特定浓度显示与ＬＡＫ细胞有协同作用。
The lung adenocarcinoma cell line A549 was used as target cells to investigate the synergistic effect of LAK cells and anticancer drugs in killing tumor cells. After treated with 3 kinds of anti-tumor drugs, such as Mycobacterium phlei C, doxorubicin and cisplatin at concentration of 10μg / ml ~ 0.155μg / ml for 24 or 4 hours, A549 cells were added with LAK cells and measured by lactate dehydrogenase release Cytotoxic effects. The results showed that mitomycin did not change the sensitivity of spermatid to LAK cells. Adriamycin increased the killing effect of LAK cells on tumor cells with increasing concentration. While cisplatin showed a synergistic effect with LAK cells at specific concentrations.