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目的:为临床合理应用缩宫素催产引产提供参考。方法:对发现的45例缩宫素致子宫强直性收缩的不良反应(ADR)进行统计,分析患者基本情况、给药途径、用法用量及ADR发生时间、临床表现、处理与转归等。结果与结论:45例ADR中,27例孕次为2次以上,25例产次为1次或以上;症状发生时间集中在用药11~20 min,发生迅速;予吸氧和硫酸镁治疗后,40例症状在10min内缓解。个体对缩宫素的敏感性呈高度差异化,主要受缩宫素受体的密度和活性、缩宫素剂量以及子宫生理状态等的影响。为做到合理用药,避免子宫强直性收缩等不良反应的发生,须充分了解患者情况,进行个体化用药。
Objective: To provide a reference for the clinical application of oxytocin oxytocin induced labor. Methods: Forty-five cases of oxytocin-induced uterine ankylosis induced adverse reactions (ADR) were statistically analyzed. The patients’ basic condition, administration route, dosage and the time, clinical manifestation, treatment and prognosis of ADR were analyzed. RESULTS AND CONCLUSION: In 45 cases of ADR, 27 cases were more than 2 times of pregnancy and 25 cases were given 1 time or more. The time of symptom occurred in 11-20 minutes after treatment, which was rapid. After being treated with oxygen and magnesium sulfate , 40 cases of remission within 10min. The individual’s sensitivity to oxytocin is highly differentiated, mainly by the density and activity of oxytocin receptors, oxytocin doses and physiological status of the uterus. In order to achieve rational use of drugs to avoid the occurrence of adverse reactions such as tonic contraction of the uterus, we must fully understand the patient’s situation, the individual medication.