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目的探讨奥美拉唑对反流性食管炎期间幽门螺杆菌 (Hp)的治疗作用。方法随机选取我院门诊及住院患者 1 86例 ,依据是否有幽门螺杆菌感染分为实验组与对照组。比较两组用奥美拉唑 +西沙必利治愈率及缓解率。结果反流性食管炎患者Hp感染率为 36 %。Hp感染组 4周后的缓解率及治愈率分别为 92 .5 %和 82 .1 % ;8周后分别为 97.0 .%和 94.0 % ;非感染组 4周的缓解率及治愈率分别为 83 .1 %和 73 .9% ,8周后分别为 90 .7%和 89.0 %。两组比较缓解率、治愈率均有显著性差异 (P <0 .0 5 ,P <0 .0 1 )。结论反流性食管炎伴Hp感染者采用质子泵抑制剂治疗 ,效果明显好于非感染者
Objective To investigate the therapeutic effect of omeprazole on Helicobacter pylori (Hp) during reflux esophagitis. Methods One hundred and sixty-six outpatients and inpatients in our hospital were randomly selected and divided into experimental group and control group according to the presence or absence of Helicobacter pylori infection. Compare the two groups with omeprazole + cisapride cure rate and remission rate. Results Hp infection rate in patients with reflux esophagitis was 36%. The remission rate and cure rate of Hp infection group after 4 weeks were 92.5% and 82.1% respectively, 97.0% and 94.0% after 8 weeks respectively. The remission rate and cure rate of non-infected group at 4 weeks were 83 .1% and 73 .9% respectively, 90.7% and 89.0% respectively after 8 weeks. There was significant difference between the two groups (P <0.05, P <0.01). Conclusions Reflux esophagitis with Hp infection was treated with proton pump inhibitor, the effect was significantly better than non-infected