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目的探讨不稳定型心绞痛(UA)患者应用辛伐他汀治疗10天后血清C-反应蛋白(CRP)的含量变化。方法80例不稳定型心绞痛患者随机分为辛伐他汀组(A组n=40)和常规治疗组(B组n=40),辛伐他汀组在常规治疗基础上加服辛伐他汀(20mg/d),治疗10天,治疗前后10天分别测定血清CRP和血脂水平,另设健康对照组(C组n=30)。结果(1)治疗前UA患者与健康者血清CRP的含量差异有显著性(P<0.01);(2)治疗10天后2组患者血清CRP的含量差异有显著性(P<0.05)。治疗前后两组患者的血脂成分差异无显著性(P>0.05)。结论早期应用辛伐他汀治疗可显著降低UA患者血清C-反应蛋白的水平,使UA患者获益。
Objective To investigate the changes of serum C-reactive protein (CRP) levels in patients with unstable angina pectoris (UA) treated with simvastatin for 10 days. Methods Eighty patients with unstable angina were randomly divided into simvastatin group (n = 40 in group A) and conventional treatment group (n = 40 in group B). Simvastatin group was given simvastatin (20mg / d). After 10 days of treatment, serum CRP and blood lipid levels were measured before and after treatment. Another healthy control group (n = 30 in group C) was also established. Results (1) There was significant difference in serum CRP levels between UA patients and healthy controls before treatment (P <0.01). (2) The levels of serum CRP in two groups of patients after 10 days of treatment were significantly different (P <0.05). Before and after treatment, there was no significant difference in the lipid composition between the two groups (P> 0.05). Conclusions The early application of simvastatin can significantly reduce the level of serum C-reactive protein in patients with UA and benefit patients with UA.