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本工作在6只胰瘻狗(其中3只同时带有巴索夫胃瘻)上进行,向十二指腸腸腔內重复注入稀盐酸引起胰液分泌,一共作了78次实驗,其主要結果如下: (一)在正常以及頸部迷走封閉与膈上迷走切断的情况下,腸內重复注酸后胰液分泌量一直維持在一个一定高度的水平;脂肪酶与胰蛋白酶活性的变化进程呈现平行关系。 (二)在上述三种情况下,靜脉注入氯丙嗪(1毫克/公斤)都大幅度地降低胰液分泌量达两小时以上;同时,脂肪酶与胰蛋白酶活性的平行关系发生紊乱,由此說明氯丙嗪对胰腺液体的分泌具有抑制作用,对胰酶活性的平行变化則有分离作用,而且不是以迷走神經为其作用途径。 (三)文中討論了氯丙嗪作用的可能机制。
This work was performed on 6 dogs with pancreatic fistula, of which 3 were accompanied by Basov’s gastric fistula. Repeated injection of diluted hydrochloric acid into the duodenum intestine caused secretion of pancreatic juice. A total of 78 experiments were performed. The main results are as follows: ( A) In the normal and vaginal closure of the vagina and the diaphragm on the vagina off the case of intestinal excretion of pancreatic juice after repeated injection of acid secretion has been maintained at a certain level; lipase and trypsin activity showed a parallel relationship between the progress. (B) In all three cases, intravenous injection of chlorpromazine (1 mg / kg) significantly reduced pancreatic juice secretion for more than two hours; at the same time, the parallel relationship between lipase and trypsin activity was disrupted, This shows that chlorpromazine has inhibitory effect on the secretion of pancreatic fluid, and has parallel effect on the change of pancreatic enzyme activity, and does not take the vagus nerve as the way of its action. (Three) the paper discussed the possible mechanism of chlorpromazine.