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经硬脑膜对视皮层电刺激为视觉功能修复提供了一种新的技术思路。前期的仿真工作利用激活函数定性研究了经硬脑膜电刺激对视皮层的作用效果,本研究在原有模型基础上引入神经元模型,定量研究不同刺激波形及参数对电极作用范围的影响。该方法将已建立的神经元模型耦合到视皮层区域有限元模型中,利用傅里叶-有限元方法分别计算双脉冲、指数脉冲和正弦波刺激下视皮层区域模型内的场电位,将电位加载到神经元模型上,观察神经元是否发生兴奋,以神经元区域兴奋个数判定电极的作用范围。仿真结果表明,该方法能较好的表达刺激的响应范围:不同刺激波形及参数引起的神经元区域兴奋数量不同,且解剖结构会影响刺激效果。所得结果对实验具有一定指导意义。
The dura to visual cortex electrical stimulation for visual function repair provides a new technical ideas. The pre-simulation work used the activation function to qualitatively study the effects of dural electrical stimulation on the visual cortex. In this study, based on the original model, a neuron model was introduced to quantitatively study the influence of different stimulation waveforms and parameters on the electrode action range. In the method, the established neuron model is coupled to the visual cortex region finite element model. The field potential in the visual cortex region model is calculated by using the Fourier-finite element method under the double pulse, the exponential pulse and the sine wave respectively. The potential Loaded onto the neuron model to observe whether the excitability of the neuron occurs and determine the range of action of the electrode by the number of excitations in the neuron region. The simulation results show that this method can well express the response range of stimuli: the number of excitations in neuronal regions caused by different stimulus waveforms and parameters is different, and the anatomical structure will affect the stimulation effect. The results obtained for the experiment has some guiding significance.