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在最新一期的《自然》(Nature)杂志上两个研究小组将肿瘤的耐药机制指向了同一基因--FBW7。这一研究发现有助于肿瘤学家预测化疗患者将对紫杉醇及类似活性药物产生的药物反应,并为癌症治疗指明了新的研究靶点。紫杉醇是目前临床上应用最广泛的一类化疗药物。紫杉醇可通过促进微管聚合和稳定已聚合微管导致细胞内大量微管积聚,从而最终干
In the latest issue of Nature, two research groups point to the tumor’s resistance mechanism to the same gene, FBW7. The study found that oncologists may be able to predict the chemotherapeutic response of patients undergoing chemotherapy to paclitaxel and similar active drugs and to point out new research targets for the treatment of cancer. Paclitaxel is currently the most widely used class of chemotherapy drugs. Paclitaxel can eventually induce the accumulation of microtubules in the cells by promoting microtubule polymerization and stabilizing the polymerized microtubules so that the final dry