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目的探讨FAS-670A/G多态性与宫颈癌易感性之间的关系。方法全面检索相关文献,收集2012年1月前有关FAS-670A/G多态性与宫颈癌易感性的病例对照研究,使用Stata 10.0进行Meta分析。结果最终纳入病例对照研究10项,累计病例2174例,对照2514例。在显性模型、隐性模型、加性模型中,Meta分析的OR值及95%CI分别为1.08(0.83-1.41)、0.99(0.76-1.30)、1.03(0.91-1.17),且按种族所进行的分层分析中各OR值均未达到显著性水平。结论 FAS-670A/G多态性与宫颈癌易感性之间无显著关联。
Objective To investigate the relationship between FAS-670A / G polymorphism and cervical cancer susceptibility. Methods A comprehensive literature search was conducted to collect a case-control study of the association between FAS-670A / G polymorphism and susceptibility to cervical cancer before January 2012 and Meta-analysis using Stata 10.0. Results Finally included in the case-control study of 10, a total of 2174 cases, control of 2514 cases. In the dominant model, implicit model and additive model, the OR and 95% CI of Meta analysis were 1.08 (0.83-1.41), 0.99 (0.76-1.30) and 1.03 (0.91-1.17) respectively, The stratified analysis did not reach any significance level. Conclusion There is no significant correlation between FAS-670A / G polymorphism and cervical cancer susceptibility.