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目的 :探讨豚鼠耳蜗底回接近末端局部微循环障碍的听力损伤特点 ,建立以高频损伤为主的听力损伤模型。方法 :采用光化学法诱导豚鼠耳蜗底回接近末端 1/ 2段微循环障碍 ;常规火棉胶切片观察耳蜗形态学变化 ;Madsen2 2 5 0诱发电位系统记录各频率的耳蜗神经复合动作电位 (CAP)。结果 :各频率的 CAP N1 潜伏期、CAP阈移、CAP N1 振幅变化 ,提示其听力损伤以高频较重 ,组织病理学变化表明耳蜗形态学改变主要局限于耳蜗底回接近末端 1/ 2段。结论 :耳蜗底回接近末端局部微循环障碍可以导致高频范围为主的听力损伤。
Objective: To investigate the characteristics of hearing impairment in the proximal gyrocephalus near the cochlear gyri in guinea pigs, and to establish a hearing impairment model based on high frequency injury. Methods: The photocoagulation method was used to induce microcirculation disturbance in proximal segment of cochlear of proximal guinea pig in 1/2 segments. Morphology of cochlear was observed with conventional collodione gel. The sensory system of Madsen225 evoked potential was used to record cochlear nerve complex action potential (CAP) . Results: The change of CAP N1 latency, CAP threshold shift and CAP N1 amplitude at each frequency indicated that the hearing impairment was severe at high frequency. Histopathological changes indicated that the morphological changes of the cochlea were mainly confined to the proximal part of the cochlea. CONCLUSIONS: Local cochlear proximal approach to distal microcirculation can lead to hearing loss in the high frequency range.