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目的：研究蛋白激酶Ｃ抑制剂Ｃｈｅｌｅｒｙｔｈｒｉｎｅ对大鼠脑缺血时纹体γ－氨基丁酸（ＧＡＢＡ）和甘氨酸（Ｇｌｙ）释放的影响。方法：用微透析和高压液相法测定大鼠半球缺血时纹体ＧＡＢＡ和Ｇｌｙ的释放。结果：脑缺血时纹体ＧＡＢＡ和Ｇｌｙ的释放明显升高。前者被Ｃｈｅｌｅｒｙｔｈｒｉｎｅ促进而后者则被抑制。结论：脑缺血时纹体ＧＡＢＡ和Ｇｌｙ释放的明显升高参与了脑缺血病理过程，蛋白激酶Ｃ抑制剂Ｃｈｅｌｅｒｙ－ｔｈｒｉｎｅ可能通过这一机制具有某些保护缺血大脑的作用
AIM: To investigate the effects of Chelerythrine, a protein kinase C inhibitor, on the release of GABA and Gly from the striatum during cerebral ischemia in rats. Methods: The release of GABA and Gly from the striatum during hemispheric ischemia in rats was determined by microdialysis and high pressure liquid chromatography. Results: The release of GABA and Gly in the striatum was significantly increased after cerebral ischemia. The former is promoted by Chelerythrine while the latter is suppressed. CONCLUSION: The significant increase of GABA and Gly release during cerebral ischemia is involved in the pathological process of cerebral ischemia. Chelery-thrine, a protein kinase C inhibitor, may have some protective effects on ischemic brain through this mechanism