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由于铍的历史短和它的不寻常的毒性机制,人们对铍病尚不完全了解。本文综述人类铍病的临床、流行病学、铍的非恶性呼吸道效应的体内和体外的实验研究,并概括铍的肺效应研究的结果,综合成铍的肺毒性模型,阐明了铍病的某些疑难问题。虽然,煤燃烧是居民接触铍的主要来源,它占排放到美国环境大气中的铍总量的90％以上。但是,城市地区的大气中的铍水平很低,职业性接触铍才是人类的主要危害。
Due to the short history of beryllium and its unusual toxicity mechanisms, people are not fully aware of beryllium disease. This review summarizes the clinical and epidemiological studies of human beryllium in vivo and in vitro in the non-malignant airway effects of beryllium, and summarizes the results of the lung effect study of beryllium and synthesizes the lung toxicity model of beryllium to elucidate the Some difficult questions. Although coal combustion is the main source of household exposure to beryllium, it accounts for more than 90% of the total beryllium that is released into the atmosphere of the United States. However, the level of beryllium in urban areas is very low and occupational exposure to beryllium is the major human hazard.