嗅神经细胞肿瘤的命名较混乱,包括嗅神经上皮瘤、神经母细胞瘤及神经细胞瘤等。Silva等根据光镜及电镜下细胞形态学特征,将其分为神经内分泌癌及神经母细胞瘤二类,后者再分为带有或不带有嗅细胞分化的二种。生长部位为鼻腔、鼻窦和喉部。本病原发部位尚难肯定,Silva等认为神经内分泌性肿瘤与神经母细胞瘤皆起源于嗅粘膜的基底细胞。病理特征:经嗜银染色在胞质内可见有界膜的颗粒。这些分泌性颗粒集中于胞质突起处,也可存在于神经母细胞瘤、副神经节瘤及类癌瘤中。在光学显微镜下可见细胞巢被结缔组织包绕,境界分明。有些病例还可出现 The names of olfactory nerve cell tumors are more confusing, including olfactory neuroepithelial neoplasia, neuroblastoma, and neuroblastoma. Silva et al. classified them into neuroendocrine carcinomas and neuroblastomas according to their morphological characteristics under light and electron microscopy. The latter were further divided into two types with or without olfactory cell differentiation. The sites of growth were nasal cavity, sinuses and throat. The pathogenic site of this disease is still difficult to confirm, Silva, etc. that neuroendocrine tumors and neuroblastoma originate from the basal cells of the olfactory mucosa. Pathological features: There are particles of bounded membranes in the cytoplasm after silver staining. These secretory granules are concentrated in cytoplasmic processes and may also be present in neuroblastoma, paraganglioma, and carcinoid tumors. Under the light microscope, the cell nest is surrounded by connective tissue and the boundary is clear. Some cases can also appear