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为从红细胞免疫角度探讨系膜增生性肾小球肾炎(MsPGN)患儿的免疫发病机制,用郭峰法检测了31例MsPGN的红细胞和白细胞免疫粘附功能,并进行比较研究。结果提示:(1)作为检测红细胞免疫粘附功能的红细胞C3b受体花环率(RCR)和肿瘤红细胞花环率(TRR)均较对照组明显降低,红细胞免疫复合物花环率(RICR)差异不显著。(2)作为检测白细胞免疫粘附功能的肿瘤粒细胞花环率(TNR)和肿瘤淋巴细胞花环率(TLR)均较对照组降低,(3)红细胞和白细胞免疫粘附功能的下降程度呈显著正相关。结论:红细胞和白细胞免疫粘附功能紊乱可能是MsPGN的发病机理之一。提高红细胞和白细胞免疫粘附功能,可能为临床治疗MsPGN提供新思路。RCR、RICR、TRR、TNR、TLR均可作为判断病情、疗效、预后的指标而应用于临床。
In order to explore the immune pathogenesis of children with mesangial proliferative glomerulonephritis (MsPGN) from the perspective of erythrocyte immune function, the immune function of erythrocytes and leucocytes in 31 cases of MsPGN was detected by GuoFeng method and compared. The results suggest that: (1) RBC and TRR of erythrocytes as a measure of erythrocyte immune adherence were significantly lower than those of the control group, while the RICR of erythrocyte immune complex was not significantly different . (2) Compared with the control group, the TNM and TLR of leukocytes as a measure of leukocyte adhesion were significantly lower than that of the control group (3) The decrease of erythrocyte and leukocyte immune adherence was significantly positive Related. Conclusion: Erythrocyte and leukocyte dysfunction may be one of the pathogenesis of MsPGN. Increasing the immune adherence function of erythrocytes and leukocytes may provide new ideas for clinical treatment of MsPGN. RCR, RICR, TRR, TNR, TLR can be used as clinical indicators to determine the disease, efficacy, prognosis.