新生儿因免疫功能不成熟而易患严重致死性感染。早产儿、极低体重儿、小于胎龄儿等高危新生儿感染起病急骤,预后更差。新生儿免疫系统不能及时对感染病原菌产生特异性免疫球蛋白G(IgG),仅有少量IgM合成。近年用静脉丙种球蛋白G(Intravenous Immunoglobulin,IVIG)治疗新生儿感染性疾病取得良好疗效。本文报告应用国产IVIG和敏感抗生素治疗重症感染新生儿20例临 Neonates are predisposed to severe lethal infections due to immature immune function. Premature children, very low birth weight children, less than gestational age neonates and other high-risk infection in the sudden onset, the prognosis worse. Neonatal immune system can not timely produce specific immunoglobulin G (IgG) on infected pathogens, only a small amount of IgM synthesis. In recent years, intravenous gamma globulin G (Intravenous Immunoglobulin, IVIG) treatment of neonatal infectious diseases achieved good results. This article reports the application of domestic IVIG and sensitive antibiotics in the treatment of severe infection in 20 newborns