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目的探讨结直肠癌(CRC)患者的血清乳酸脱氢酶(LDH)水平变化及其检测价值分析。方法选择75例CRC患者作为CRC组,另选取75例健康体检者作为对照组,比较2组的LDH水平以及不同肿瘤发病部位、肿瘤分期、分化程度、淋巴结转移以及生存状态下患者的血清LDH水平,并分析LDH与其他因素的相关性。结果 CRC组的血清LDH水平显著高于对照组,差异有统计学意义(P<0.05);结肠癌与直肠癌患者的血清LDH水平比较,差异无统计学意义(P>0.05);随着肿瘤分期的增加,血清LDH水平显著升高;淋巴结转移患者高于无转移患者,死亡者高于存活者,差异均有统计学意义(P<0.05)。相关性分析结果表明,患者血清LDH水平与肿瘤分期、淋巴结的转移以及存活状态均呈正相关性(P<0.01),与分化程度呈显著负相关(P<0.01)。结论 CRC患者的血清LDH水平异常升高,LDH水平监测对CRC病情的发展以及预后预示具有一定的临床意义。
Objective To investigate the changes of serum lactate dehydrogenase (LDH) levels in patients with colorectal cancer (CRC) and analyze their detection value. Methods Seventy-five patients with CRC were selected as CRC group, and another 75 healthy subjects were selected as control group. The levels of serum LDH were compared between the two groups, including LDH levels, tumor location, tumor differentiation, lymph node metastasis, and survival. , and analyze the correlation of LDH and other factors. Results Serum LDH levels in the CRC group were significantly higher than those in the control group (P<0.05). There was no significant difference in serum LDH levels between colon cancer patients and rectal cancer patients (P>0.05); With the increase of staging, serum LDH levels increased significantly; patients with lymph node metastasis were higher than those without metastasis, and those who died were higher than survivors. The difference was statistically significant (P<0.05). Correlation analysis showed that serum LDH levels were positively correlated with tumor stage, lymph node metastasis, and survival status (P<0.01), and negatively correlated with differentiation (P<0.01). Conclusion Serum LDH levels in CRC patients are abnormally elevated. Monitoring of LDH levels has certain clinical significance for the development of CRC conditions and prognosis.