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目的 :探讨N -乙酰半胱氨酸 (NAC)治疗稳定期慢性阻塞性肺疾病 (COPD)患者疗效。方法 :选择 70例符合入选标准的COPD患者 ,随机分为治疗组 ( 3 6例 )和对照组 ( 3 4)例 ,治疗组在常规治疗基础上 ,加用NAC( 60 0mg ,每日 1次 ,连用 2月 ) ;对照组仅给予常规治疗。 2月后观察两组呼吸功能的变化。结果 :2月后 ,治疗组第一秒用力呼气容积 (FEV1)、用力肺活量 (FVC)、一氧化碳弥散能力 (DLCO)和最大自主通气 (MVV)较治疗前有显著改善 (P <0 0 5 ) ,对照组治疗前后无明显改善 (P >0 0 5 )。结论 :COPD体内存在氧化 -抗氧化失衡 ,治疗加用抗氧化剂可改善机体的通气及弥散功能。
Objective: To investigate the efficacy of NAC in patients with stable chronic obstructive pulmonary disease (COPD). Methods: Seventy COPD patients who met the inclusion criteria were randomly divided into treatment group (36 cases) and control group (34 cases). The treatment group was treated with NAC (60 mg, once daily , Used in conjunction with February); control group only given conventional treatment. Two months after the observation of changes in respiratory function. Results: After 2 months, FEV1, FVC, DLCO and MVV in treatment group were significantly improved (P <0.05) ), No significant improvement in the control group before and after treatment (P> 0 05). Conclusion: There is oxidation-antioxidant imbalance in COPD. The treatment plus antioxidants can improve the ventilation and dispersion of the body.