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目的:采用临床多中心研究方法评价国产注射用阿奇霉素治疗细菌性感染的临床疗效和安全性。方法:302例患者分为呼吸系统感染组(181例)和其他系统感染组(121例)。给药方法为阿奇霉素0.5g,每天1次,静脉滴注,疗程5天～7天。结果:阿奇霉素治疗总的临床痊愈率为72.8％,有效率为93.4％,其中呼吸系统感染的痊愈率为60.8％,有效率为90.1％;其他系统感染的痊愈率为90.9％,有效率为98.3％。细菌清除率为97.7％。应用阿奇霉素后的不良反应发生率为9.6％。结论:国产注射用阿奇霉素治疗细菌性感染有效且安全。
Objective: To evaluate clinical efficacy and safety of domestic injection azithromycin in the treatment of bacterial infections by clinical multicenter study. Methods: 302 patients were divided into respiratory infection group (181 cases) and other systemic infection group (121 cases). Administration method for azithromycin 0.5g, 1 day, intravenous infusion, treatment of 5 days to 7 days. Results: The total clinical cure rate of azithromycin was 72.8% and the effective rate was 93.4%. The cure rate of respiratory infection was 60.8% and the effective rate was 90.1%. The cure rate of other systemic infections was 90.9% and the effective rate was 98.3 %. Bacterial clearance rate was 97.7%. The incidence of adverse reactions after azithromycin was 9.6%. Conclusion: Domestic injection azithromycin is effective and safe in the treatment of bacterial infections.