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目的分析高同型半胱氨酸血症与年轻原发性高血压患者肾功能的关系。方法选择原发性高血压患者93例,根据血浆同型半胱氨酸水平分为H型高血压组(血浆同型半胱氨酸≥10μmol/L)45例与普通高血压组(血浆同型半胱氨酸<10μmol/L)48例,比较2组患者血肌酐(Cr)、血尿素氮(BUN)、肾小球滤过率(e GFR)、24 h尿蛋白及24 h尿微量白蛋白。并分析血浆同型半胱氨酸水平与24 h尿微量白蛋白的相关性。结果 2组患者Cr、BUN、e GFR、24 h尿蛋白比较差异均无统计学意义(P>0.05);H型高血压组24 h尿微量白蛋白明显高于普通高血压组(P<0.05)。血浆同型半胱氨酸水平与24 h尿微量白蛋白存在正相关(r=0.352,P<0.05)。结论高同型半胱氨酸血症与年轻原发性高血压患者极早期肾功能损害呈正相关。
Objective To analyze the relationship between hyperhomocysteinemia and renal function in young patients with essential hypertension. Methods Ninety-three patients with essential hypertension were divided into Hypertension group (plasma homocysteine ≥10μmol / L) and Hypertension group (HbA1c) according to the plasma homocysteine level 48 cases. Serum creatinine (Cr), blood urea nitrogen (BUN), glomerular filtration rate (e GFR), 24 h urinary protein and 24h urine microalbumin were compared between the two groups. And analyze the correlation between plasma homocysteine level and 24-hour urine microalbumin. Results There was no significant difference in Cr, BUN, eGFR and 24 h urinary protein between the two groups (P> 0.05). The 24-hour urinary albumin in Hypertension group was significantly higher than that in the general hypertension group (P <0.05) ). Plasma homocysteine levels were positively correlated with 24-h urine microalbumin (r = 0.352, P <0.05). Conclusions Hyperhomocysteinemia is positively correlated with very early renal dysfunction in young patients with essential hypertension.