乳腺癌已成为妇女最常见的恶性肿瘤,其发病率占妇女恶性肿瘤第一位,且有逐年上升趋势。乳腺癌的远处转移缩短了无病生存期,增加了病死率,也是目前临床上的治疗难点。而肿瘤的侵袭与转移是一个主动过程,与白细胞迁移有许多相似之处,由趋化因子及其受体严密调控。肿瘤细胞一般会? Breast cancer has become the most common malignant tumor in women, the incidence of which ranks first in women’s malignancies, and there is an upward trend year by year. The distant metastasis of breast cancer shorten the disease-free survival and increase the mortality, but also the clinical treatment of the current difficulties. Tumor invasion and metastasis is an active process that has many similarities with leukocyte migration and is closely regulated by chemokines and their receptors. Tumor cells generally?