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幼年型糖尿病和动物的实验性糖尿病常伴血浆胰岛素,高血糖素和胰多肽浓度异常。胰岛素和高血糖素对脂质的生物合成作用相反。这些激素都对脂质的代谢起调节作用。很多资料提示,倘能纠正糖尿病的代谢异常就能预防糖尿病的晚期并发症,但传统的胰岛素疗法达不到这一目的。在链佐霉素-糖尿大鼠的实验研究中,胰腺移植术能控制血浆葡萄糖和胰岛素水平,恢复正常的葡萄糖耐量;但对糖尿病引起的高血糖素血症和脂血症的影响知道得很少,对血浆胰多肽浓度的影响则一无所知。本文目的在于研究胰腺移植术对糖尿病性脂质代谢和血浆胰腺激素的长期影响。材料和方法:用纯系雄性年龄三个月左右Wistar
Juvenile diabetes and animal experimental diabetes are often associated with abnormal plasma insulin, glucagon and pancreatic polypeptide concentrations. The effects of insulin and glucagon on lipid biosynthesis are reversed. These hormones all play a regulatory role in lipid metabolism. Many sources suggest that if the metabolic abnormalities of diabetes can prevent the late complications of diabetes, traditional insulin therapy can not achieve this goal. In an experimental study of streptozotocin-diabetic rats, pancreas transplantation can control plasma glucose and insulin levels and restore normal glucose tolerance; however, the effects on diabetes-induced hyperglycemia and lipidemia are well known Little, no effect on plasma pancreatic polypeptide concentration. This article aims to study the long-term effects of pancreatic transplantation on diabetic lipid metabolism and plasma pancreatic hormones. MATERIALS AND METHODS: Pure lines of males were about 3 months old and about Wistar