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Moore氏等于1965年在脑蛋白的研究中,首先发现S-100蛋白,其分子量较小(20,000～25,000),不耐热,是一种含钙酸性蛋白,能溶于100％硫酸铵,因而得名。阳性颗粒存在于细胞核和细胞浆中。主要分布在神经组织、黑色素细胞、肌上皮、软骨、脊索瘤、嗜酸性内芽肿及类癌等。由于S-100蛋白分布较广泛,给恶性肿瘤的鉴别诊断带来一定的困难。本文分析了48例恶性肿瘤的S-100蛋白标记结果,并对26例恶性黑色素瘤、2例皮肤色素痣进行了免疫
Moore’s is equal to 1965 in brain protein research, first found S-100 protein, its small molecular weight (20,000 ~ 25,000), not heat, is a calcium-containing acidic protein, soluble in 100% ammonium sulfate, Get its name. Positive particles are present in the nucleus and cytoplasm. Mainly distributed in nervous tissue, melanocytes, myoepithelial, cartilage, chordoma, eosinophilic granulomatous and carcinoid. Due to the wide distribution of S-100 protein, it has brought certain difficulties to the differential diagnosis of malignant tumors. This article analyzed the results of S-100 protein labeling of 48 cases of malignant tumors, and immunized 26 cases of malignant melanoma and 2 cases of skin nevus pigmentation.