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①目的比较奥曲肽与神经垂体素联合硝酸甘油治疗食管静脉曲张破裂出血( EVB)的效果。②方法将45例经胃镜证实的肝硬化EVB病人随机分为奥曲肽组(n=23)和联合组(n=22),奥曲肽组给予奥曲肽治疗,联合组给予神经垂体素联合硝酸甘油治疗,通过胃管抽吸胃内容物观察止血情况,并记录药物的不良反应。③结果奥曲肽组12及24h内的完全止血率分别为47.83%和78.26%,略高于联合组的45.45%和72.73%,但差异无显著性(x2=0.76,1.18,P>0.05);两组病人治疗后7d内的再出血率为 11.11%和 18.75%,差异亦无显著性(x2=2.13,P>0.05)。两组不良反应发生率分别为8.70%和31.18%,差异有显著性(x2=19.18,P<0.01),但均无严重不良反应。④结论奥曲肽与神经垂体素联合硝酸甘油治疗均能安全、有效控制EVB.
Objective To compare the efficacy of octreotide and neurophysin in combination with nitroglycerin in the treatment of esophageal variceal bleeding (EVB). Methods Forty-five patients with cirrhosis EVB confirmed by gastroscope were randomly divided into octreotide group (n = 23) and combination group (n = 22). The octreotide group was treated with octreotide, and the combination group was given neurophysin combined with nitroglycerin. Gastric tube aspiration to observe the contents of the stomach to stop bleeding, and record adverse drug reactions. Results The complete hemostasis rates of octreotide at 12 and 24 h were 47.83% and 78.26%, respectively, which were slightly higher than 45.45% and 72.73% of the combined group, respectively. However, the difference was not significant (x2 = 0. 76,1.18, P> 0.05). The rates of rebleeding within 7 days after treatment in both groups were 11.11% and 18.75%, respectively, with no significant difference (x2 = 2.13, P> 0 .05). The incidence of adverse reactions in the two groups were 8.70% and 31.18%, respectively, with significant difference (x2 = 19.18, P <0.01), but no serious adverse reactions. ④ Conclusion Both octreotide and neurotropin plus nitroglycerin can safely and effectively control EVB.