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目的探讨COX-2蛋白在鼻咽癌组织中的表达情况及其与生存素(Survivin)表达的关系和临床意义。方法采用免疫组织化学二步法检测43例鼻咽癌组织中COX-2和Survivin的表达。结果COX-2和Survivin在鼻咽癌组织中的阳性表达率分别为79.1%(33/43)和76.7%(32/43),COX-2在Ⅳ期病例中的阳性表达率为100%(14/14),并与Survivin的表达存在着显著的正相关性。结论COX-2的过度表达在鼻咽癌的发生进展过程中起着重要的作用,与抑制细胞的凋亡过程密切相关。
Objective To investigate the expression of COX-2 protein in nasopharyngeal carcinoma and its relationship with the expression of Survivin and its clinical significance. Methods Immunohistochemistry was used to detect the expression of COX-2 and Survivin in 43 cases of nasopharyngeal carcinoma. Results The positive rates of COX-2 and Survivin in nasopharyngeal carcinoma were 79.1% (33/43) and 76.7% (32/43), respectively. The positive rate of COX-2 in stage Ⅳ was 100% 14/14), and there was a significant positive correlation with Survivin expression. Conclusion Overexpression of COX-2 plays an important role in the progression of nasopharyngeal carcinoma and is closely related to the inhibition of apoptosis.