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目的:探讨中国苏皖地区汉族人群C反应蛋白(CRP)基因启动子T-757C多态性与急性心肌梗死(AMI)的相关性。方法:以303例AMI患者(AMI组)和282例非冠心病者(对照组)作为研究对象,应用聚合酶链反应-限制性片段长度多态性方法检测CRP基因T-757C多态性。结果:与对照组相比,AMI组的TC基因型频率明显增高(31.2%∶41.3%,P<0.05),TT和CC基因型以及T等位基因频率分布差异无统计学意义(P>0.05)。在调整冠心病相关危险因素并经多元logistic回归分析显示,CRP基因T-757C多态性TC基因型与AMI的发生仍呈显著性相关(OR=1.650,95%CI:1.031～2.640,P<0.05)。结论:在中国苏皖地区汉族人群中,CRP基因启动子T-757C多态性与AMI的发病密切相关。
Objective: To investigate the association between T-757C polymorphism of C-reactive protein (CRP) gene promoter and acute myocardial infarction (AMI) in Chinese Han population in Jiangsu and Anhui Provinces. Methods: T-757C polymorphism of CRP gene was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 303 patients with AMI (AMI group) and 282 patients with non-coronary heart disease (control group). Results: Compared with the control group, the frequencies of TC genotypes in AMI group were significantly increased (31.2% vs 41.3%, P <0.05), but there was no significant difference in TT genotype and CC allele frequencies ). In multivariate logistic regression analysis, the risk factors of coronary heart disease were adjusted and the genotypes of T-757C polymorphism of CRP gene were still significantly correlated with AMI (OR = 1.650, 95% CI: 1.031-2.640, P < 0.05). Conclusion: T-757C polymorphism of CRP gene promoter is closely related to the pathogenesis of AMI in Han population in Jiangsu and Anhui Provinces in China.