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目的比较妊娠期高血压与正常妊娠孕妇凝血功能及血小板状态的差异。方法选取2013—2015年新疆医科大学第二附属医院妇产科收治的正常妊娠孕妇136例作为对照组,妊娠期高血压孕妇164例作为观察组。比较两组孕妇凝血四项及血小板三项检测结果。结果观察组孕妇活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)均短于对照组,血浆纤维蛋白原(FIB)水平高于对照组(P<0.05);两组孕妇凝血酶时间(TT)比较,差异无统计学意义(P>0.05)。观察组孕妇血小板计数(PLT)低于对照组,血小板平均体积(MPV)、血小板体积分布离散度(PDW)均高于对照组(P<0.05)。结论妊娠期高血压孕妇妊娠晚期处于血液高凝状态,进行凝血功能和血小板状态检测具有重要的临床指导意义。
Objective To compare the difference of coagulation function and platelet status between pregnant women with high blood pressure and normal pregnancy. Methods 136 cases of normal pregnant women admitted to Department of Obstetrics and Gynecology, Second Affiliated Hospital of Xinjiang Medical University from 2013 to 2015 were selected as the control group. 164 pregnant women with gestational hypertension were selected as the observation group. Blood coagulation and blood platelet trigeminal test results were compared between the two groups. Results The activation partial thromboplastin time (APTT) and prothrombin time (PT) of pregnant women in the observation group were shorter than those in the control group, and the levels of fibrinogen (FIB) in the observation group were higher than those in the control group (P <0.05) Time (TT) comparison, the difference was not statistically significant (P> 0.05). The PLT in observation group was lower than that in control group. The mean platelet volume (MPV) and platelet volume distribution (PDW) in observation group were higher than those in control group (P <0.05). Conclusion Pregnancy-induced hypertension in pregnant women in the third trimester of pregnancy in hypercoagulable state, coagulation and platelet status test has important clinical significance.