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过去的资料认为:丙二醇在低浓度下并没有什么药理作用或毒性,故广泛用作多种药物的助溶剂和食品加工业的防冻剂。但是,自1970年以来,有些资料发现,丙二醇对中枢神经系统确有一定影响,且可表现双相反应(Biphasic reaction)。我们也观察到,以丙二醇为助溶剂的药物制剂,不仅不能与水剂药物混合,而且它本身也确有明显的药理作用,并干扰其它药物的效果。药品安定注射剂Ⅰ、Ⅱ、Ⅲ,分别系常州向阳制药厂、上海第十三制药厂和西安制药厂产品,其批号依次为790706,791007和791204,
Past data suggest that propylene glycol has no pharmacological or toxic effects at low concentrations and is therefore widely used as a cosolvent for many pharmaceuticals and antifreeze in the food processing industry. However, since 1970, some data have found that propylene glycol does have some influence on the central nervous system and can exhibit a Biphasic reaction. We have also observed that pharmaceutical formulations with propylene glycol as cosolvent are not only incompatible with aqueous pharmaceuticals but also have clear pharmacological effects per se and interfere with the effectiveness of other drugs. Pharmaceutical stability injection Ⅰ, Ⅱ, Ⅲ, respectively, Changzhou Xiangyang Pharmaceutical Factory, the 13th Shanghai Pharmaceutical Factory and Xi’an Pharmaceutical Factory products, the batch number followed by 790706,791007 and 791204,