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目的:对慢性脑灌注不足对轻度认知功能障碍患者认知减退的影响予以探讨。方法:随机选取我院2013年1月至2013年12月间收治的慢性脑灌注不足患者25例,应用64层螺旋CT为患者实施CTPI检查,在患者的半卵圆中心、放射冠区、枕叶、顶、颞、额、丘脑、豆状核、小脑、脑干等选择感兴趣区(ROI)进行观察,将其作为本次研究中的观察组;同时选择同期在我院开展健康体检的正常患者25例,将其作为本次研究中的对照组,对两组患者不同脑区域之间的Mo CA评分及CBF值进行对比分析。结果:两组患者的Mo CA评分及CBF值相比较具有明显的差异,并且差异具有统计学意义;同时两组患者的记忆评分、视空间与执行功能之间的差异具有统计学意义。结论:慢性脑灌注不足患者的轻度认知功能减退现象可能与患者脑血流量的明显下降有关。
Objective: To investigate the effect of chronic cerebral hypoperfusion on cognitive decline in patients with mild cognitive impairment. Methods: Twenty-five patients with chronic cerebral hypoperfusion admitted to our hospital from January 2013 to December 2013 were randomly selected. CTPI was performed in patients with chronic cerebral hypoperfusion by using 64-slice spiral CT. Temporal lobe, thalamus, thalamus, lentiform nucleus, cerebellum, brain stem and other selected areas of interest (ROI) were observed as the observation group in this study; at the same time choose the same period in our hospital for physical examination Twenty-five normal patients were used as the control group in this study to compare the MoCA scores and CBF values between different brain regions of the two groups. Results: There was significant difference between MoCA and CBF values in two groups of patients, and the difference was statistically significant. At the same time, the difference of memory score, visual space and executive function between the two groups was statistically significant. Conclusion: The mild cognitive decline in patients with chronic cerebral hypoperfusion may be related to the significant decline of cerebral blood flow in patients.