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目的:华法林在临床中出血并发症的相关因素分析,为临床合理用药,减少不良反应提供参考。方法:回顾性分析我院心内科2011年1月～2011年6月,住院房颤病人服用华法林抗凝过程中出现明显出血并发症患者4例,分析患者因素、华法林用量、INR值及联合用药等致出血并发症的相关因素。结果:该4例房颤患者均合并多种疾病,部分患者存在肝和(或)肾功能不全,3例患者INR值高于4,均有联合应用改善循环类中成药注射液、头孢类和(或)喹诺酮类抗菌药物。结论:临床有高危出血风险患者应用华法林抗凝应密切监测INR值,关注出血并发症,同时谨慎多药联用。
Objective: Warfarin in the clinical analysis of bleeding complications, clinical rational use of drugs, reduce adverse reactions provide a reference. Methods: A retrospective analysis of our hospital from January 2011 to June 2011, hospitalized patients with atrial fibrillation warfarin anticoagulation occurred in patients with significant bleeding in 4 patients, analysis of patient factors, warfarin dosage, INR value and The combination of bleeding and other complications caused by bleeding-related factors. Results: The four patients with atrial fibrillation were complicated by various diseases. Some of them had liver and / or renal insufficiency. The INR value of three patients was higher than 4. All of them were combined to improve the circulation of Chinese patent medicine injection, cephalosporins and (Or) quinolone antibacterial drugs. CONCLUSIONS: In patients with high-risk bleeding at risk for clinical use warfarin should be closely monitored for anticoagulation, with a focus on bleeding complications and cautious multi-agent combinations.